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Article

Lymphotoxin pathway-directed, autoimmune regulator-independent central tolerance to arthritogenic collagen.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2006

Chin Robert K, Zhu Mingzhao, Christiansen Peter A, Liu Wenhua, Ware Carl, Peltonen Leena, Zhang Xuejun, Guo Linjie, Han Shuhua, Zheng Biao, Fu Yang-Xin

Abstract excerpt

Ectopic expression of peripherally restricted Ags by medullary thymic epithelial cells (mTECs) is associated with negative selection. Autoimmune regulator (AIRE) is considered to be the master regulator of these Ags. We show in this study that the ectopic expression of type II collagen (CII) in mTECs and the corresponding central tolerance to CII are AIRE independent but lymphotoxin dependent. The failure to...

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Source

Identifiers

PMID: 16785524
DOI: 10.4049/jimmunol.177.1.290

Genes

AIRE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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