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Article

Ltbetar signaling does not regulate Aire-dependent transcripts in medullary thymic epithelial cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2008

Martins Vera C, Boehm Thomas, Bleul Conrad C

Abstract excerpt

Thymic medullary epithelial cells (mTECs) play a major role in central tolerance induction by expressing tissue-specific Ags (TSAs). The expression of a subset of TSAs in mTECs is under the control of Aire (autoimmune regulator). Humans defective for AIRE develop a syndrome characterized by autoimmune disease in several endocrine glands. Aire has been proposed to be regulated by lymphotoxin beta receptor...

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Source

Identifiers

PMID: 18566406
DOI: 10.4049/jimmunol.181.1.400

Genes

AIRE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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