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Article

Lymphotoxin Pathway and Aire Influences on Thymic Medullary Epithelial Cells Are Unconnected

1 Nov 2007

Abstract excerpt

The lymphotoxin pathway is critical for the development and maintenance of peripheral lymphoid organs. Mice with deficiencies in members of this pathway lack lymph nodes and Peyer's patches and have abnormal spleen architecture. These animals also develop autoantibodies to and lymphocytic infiltrates of multiple organs, provoking speculation that the lymphotoxin pathway may play a role in central tolerance...

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Identifiers

PMID: 17947641
DOI: 10.4049/jimmunol.179.9.5693

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