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Article

Pharmacogenetics of antidepressant medication intolerance.

The American journal of psychiatry - 1 Oct 2003

Murphy Greer M, Kremer Charlotte, Rodrigues Heidi E, Schatzberg Alan F

Abstract excerpt

OBJECTIVE: The authors sought to identify genetic markers for antidepressant medication intolerance. Genetic variation in drug metabolizing enzymes such as cytochrome P450 2D6 (CYP2D6) has been postulated to underlie antidepressant intolerance (pharmacokinetic effect). However, variation in genes encoding serotonin receptors could also explain antidepressant side effects (pharmacodynamic effect). METHOD: An...

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Source

Identifiers

PMID: 14514498
DOI: 10.1176/appi.ajp.160.10.1830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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