Article
DNA microarray technology in the clinical environment: the AmpliChip CYP450 test for CYP2D6 and CYP2C19 genotyping.
CNS spectrums - 1 Jan 2009
de Leon Jose, Susce Margaret T, Johnson Maria, Hardin Mike, Maw Lorraine, Shao Alison, Allen Antonette C P, Chiafari Francis A, Hillman Grantland, Nikoloff D Michele
Abstract excerpt
INTRODUCTION: An important technological advance in genetic testing is the DNA microarray, which allows for the simultaneous testing of thousands of DNA sequences. The AmpliChip CYP450 Test employs this microarray technology for cytochrome P450 (CYP) 2D6 and CYP2C19 genotyping. Isoenzymes encoded by these genes are responsible for the metabolism of many widely prescribed drugs. The objectives of this study were...
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