Article
Association between CYP2D6 genotype and tardive dyskinesia in Korean schizophrenics.
The pharmacogenomics journal - 1 Jan 2002
Nikoloff D, Shim J C, Fairchild M, Patten N, Fijal B A, Koch W H, MacPherson A, Flockhart D, Yoon Y R, Yoon J S, Kim Y H, Shin J G
Abstract excerpt
The CYP2D6 gene codes for human cytochrome P450 2D6 enzyme, which is responsible for the metabolism of many psychiatric drugs. In schizophrenic patients treated with neuroleptics, decreased or loss of function CYP2D6 alleles may contribute to the development of tardive dyskinesia (TD), a movement disorder that frequently occurs with chronic neuroleptic treatment. The goal of this study was to determine whether...
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