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Article

Cytotoxicity of mutant huntingtin fragment in yeast can be modulated by the expression level of wild type huntingtin fragment.

ACS chemical neuroscience - 19 Mar 2014

Saleh Aliabbas Ahmedbhai, Bhadra Ankan Kumar, Roy Ipsita

Abstract excerpt

Conflicting reports exist in the literature regarding the role of wild-type huntingtin in determining the toxicity of the aggregated, mutant huntingtin in Huntington's disease (HD). Some studies report the amelioration of toxicity of the mutant protein in the presence of the wild-type protein, while others indicate sequestration of the wild-type protein by mutant huntingtin. Over the years, yeast has been...

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PMID: 24377263
DOI: 10.1021/cn400171d
PMCID: PMC3963126

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