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Article

Statistical Analysis of Pathogenicity of Somatic Mutations in Cancer

19 Jun 2006

Abstract excerpt

Recent large-scale sequencing studies have revealed that cancer genomes contain variable numbers of somatic point mutations distributed across many genes. These somatic mutations most likely include passenger mutations that are not cancer causing and pathogenic driver mutations in cancer genes. Establishing a significant presence of driver mutations in such data sets is of biological interest. Whereas current...

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Identifiers

PMID: 16783027
DOI: 10.1534/genetics.105.044677

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