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MARiO: predicting cancer variant pathogenicity by integrating in silico evaluation and patient-level mutational contexts

2026-07-10

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Comprehensive genomic profiling (CGP) supports precision medicine in cancer care, but accurate assessment of missense variant pathogenicity, especially for variants without established consensus, remains challenging. Various computational tools have been developed for variant functional prediction, but most current tools rely solely on variant-level features and do not capture the clinical context of individual pa...

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Literature Corpus work: d6742296-84ad-59ef-b1c8-34d63425472c
DOI: 10.64898/2026.07.07.736919

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MARiO: predicting cancer variant pathogenicity by integrating <i>in silico</i> evaluation and patient-level mutational contexts

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