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Article

Analytical methods for inferring functional effects of single base pair substitutions in human cancers.

Human genetics - 1 Oct 2009

Lee William, Yue Peng, Zhang Zemin

Abstract excerpt

Cancer is a genetic disease that results from a variety of genomic alterations. Identification of some of these causal genetic events has enabled the development of targeted therapeutics and spurred efforts to discover the key genes that drive cancer formation. Rapidly improving sequencing and genotyping technology continues to generate increasingly large datasets that require analytical methods to identify...

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PMID: 19434427
DOI: 10.1007/s00439-009-0677-y
PMCID: PMC2762536

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