Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Three-locus and four-locus QTL interactions influence mouse insulin-like growth factor-I.

Physiological genomics - 16 Jun 2006

Hanlon Philip, Lorenz William Andrew, Shao Zhihong, Harper James M, Galecki Andrzej T, Miller Richard A, Burke David T

Abstract excerpt

A previous analysis of serum insulin-like growth factor I (IGF-I) levels in a mouse population (n = 961) derived from a cross of (BALB/cJ x C57BL/6J) F1 females and (C3H/HeJ x DBA/2J) F1 males documented quantitative trait loci (QTL) on chromosomes 1, 10, and 17. We employed a newly developed, random walk-based method to search for three- and four-way allelic combinations that might influence IGF-I levels through...

Topics

Join the communities discussing this publication.

Algorithms
Chromosome Walking
Crosses, Genetic
Epistasis, Genetic
Insulin-Like Growth Factor I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Mice, Inbred C3H

Mice, Inbred DBA

Source

Open in PubMed Open full text

Identifiers

PMID: 16782841
DOI: 10.1152/physiolgenomics.00247.2005
PMCID: PMC1993916

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Three-locus and four-locus QTL interactions influence mouse insulin-like growth factor-I.PMID 16782841Read ↗

Identification of genetic determinants of IGF-1 levels and longevity among mouse inbred strains.Semantic proximity Read ↗

Congenic mice provide in vivo evidence for a genetic locus that modulates serum insulin-like growth factor-I and bone acquisition.Semantic proximity Read ↗

Mapping quantitative trait loci for serum insulin-like growth factor-1 levels in mice.Semantic proximity Read ↗

Diet-dependent genetic and genomic imprinting effects on obesity in mice.Semantic proximity Read ↗

Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice.Semantic proximity Read ↗

Mapping quantitative trait loci that influence serum insulin-like growth factor binding protein-5 levels in F2 mice (MRL/MpJ X SJL/J).Semantic proximity Read ↗

Fine-mapping gene-by-diet interactions on chromosome 13 in a LG/J x SM/J murine model of obesity.Semantic proximity Read ↗

Quantitative trait loci (QTL) for lean body mass and body length in MRL/MPJ and SJL/J F(2) mice.Semantic proximity Read ↗

A Novel Mapping Strategy Utilizing Mouse Chromosome Substitution Strains Identifies Multiple Epistatic Interactions That Regulate Complex Traits.Semantic proximity Read ↗

Multidimensional genome scans identify the combinations of genetic loci linked to diabetes-related phenotypes in mice.Semantic proximity Read ↗

Widespread epistasis regulates glucose homeostasis and gene expression.Semantic proximity Read ↗

Identification of Interactive Loci Linked to Insulin and Leptin in Mice With Genetic Insulin ResistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.