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Article

Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice.

Genome research - 1 Dec 2000

Brockmann G A, Kratzsch J, Haley C S, Renne U, Schwerin M, Karle S

Abstract excerpt

Genes influencing body weight and composition and serum concentrations of leptin, insulin, and insulin-like growth factor I (IGF-I) in nonfasting animals were mapped in an intercross of the extreme high-growth mouse line DU6i and the inbred line DBA/2. Significant loci with major effects (F > 7.0...

Topics

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Animals, Outbred Strains
Crosses, Genetic
Epistasis, Genetic
Growth
Mice, Inbred A
Mice, Inbred CBA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred DBA

Quantitative Trait, Heritable

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Identifiers

PMID: 11116089
DOI: 10.1101/gr.gr1499r
PMCID: PMC313074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11116089-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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