Comparative investigation of the pathogenicity of three Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives.

doi:10.1016/j.micinf.2006.04.008

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Article

Comparative investigation of the pathogenicity of three Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives.

Microbes and infection - 1 Jul 2006

Stadthagen Gustavo, Jackson Mary, Charles Patricia, Boudou Frédéric, Barilone Nathalie, Huerre Michel, Constant Patricia, Liav Avraham, Bottova Iveta, Nigou Jérôme, Brando Thérèse, Puzo Germain, Daffé Mamadou, Benjamin Pearline, Coade Stephen, Buxton Roger S, Tascon Ricardo E, Rae Aaron, Robertson Brian D, Lowrie Douglas B, Young Douglas B, Gicquel Brigitte, Griffin Ruth

Abstract excerpt

p-Hydroxybenzoic acid derivatives (p-HBADs) are glycoconjugates secreted by all Mycobacterium tuberculosis isolates whose contribution to pathogenicity remains to be determined. The pathogenicity of three transposon mutants of M. tuberculosis deficient in the biosynthesis of some or all forms of p-HBADs was studied. Whilst the mutants grew similarly to the wild-type strain in macrophages and C57BL/6 mice, two of...

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PMID: 16782391
DOI: 10.1016/j.micinf.2006.04.008
PMCID: PMC2964916

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