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Article

Signature‐tagged and directed mutagenesis identify PABA synthetase as essential for <i>Aspergillus fumigatus</i> pathogenicity

1 Jun 2000

Abstract excerpt

Signature-tagged mutagenesis (STM) is a method that has been used to screen for genes required for in vivo survival of pathogenic bacteria, but has not been used to investigate a eukaryotic pathogen in an animal model of disease. We have adapted STM to identify genes required for in vivo growth of the opportunistic fungal pathogen Aspergillus fumigatus. Using a mouse model of invasive pulmonary aspergillosis, we...

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PMID: 10931287
DOI: 10.1046/j.1365-2958.2000.01953.x

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