Article
A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response.
Nature - 2 Sept 2004
Reed Michael B, Domenech Pilar, Manca Claudia, Su Hua, Barczak Amy K, Kreiswirth Barry N, Kaplan Gilla, Barry Clifton E
Abstract excerpt
Fifty million new infections with Mycobacterium tuberculosis occur annually, claiming 2-3 million lives from tuberculosis worldwide. Despite the apparent lack of significant genetic heterogeneity between strains of M. tuberculosis, there is mounting evidence that considerable heterogeneity exists in molecules important in disease pathogenesis. These differences may manifest in the ability of some isolates to...
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