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Article

Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production.

PLoS pathogens - 6 Jun 2008

Dao Dee N, Sweeney Kari, Hsu Tsungda, Gurcha Sudagar S, Nascimento Ivan P, Roshevsky Dan, Besra Gurdyal S, Chan John, Porcelli Steven A, Jacobs William R

Abstract excerpt

Mycobacterium tuberculosis has evolved many strategies to evade elimination by the host immune system, including the selective repression of macrophage IL-12p40 production. To identify the M. tuberculosis genes responsible for this aspect of immune evasion, we used a macrophage cell line expressing a reporter for IL-12p40 transcription to screen a transposon library of M. tuberculosis for mutants that lacked this...

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Identifiers

PMID: 18535659
DOI: 10.1371/journal.ppat.1000081
PMCID: PMC2390761

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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