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Article

Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase.

Tuberculosis (Edinburgh, Scotland) - 1 Dec 2015

Maksymiuk Christina, Ioerger Thomas, Balakrishnan Anand, Bryk Ruslana, Rhee Kyu, Sacchettini James, Nathan Carl

Abstract excerpt

We compared phenotypes of five strains of Mycobacterium tuberculosis (Mtb) differing in their expression of rv1248c and its product, 2-hydroxy-3-oxoadipate synthase (HOAS), with a focus on carbon source-dependent growth rates and attenuation in mice. Surprisingly, an rv1248c transposon mutant on a CDC1551 background grew differently than an rv1248c deletion mutant on the same background. Moreover, the same...

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Identifiers

PMID: 26547230
DOI: 10.1016/j.tube.2015.08.009
PMCID: PMC4667687

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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