Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo.

doi:10.1016/j.cub.2006.05.050

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Article

Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo.

Current biology : CB - 20 Jun 2006

Chen Li-Ying, Wang Juinn-Chin, Hyvert Yann, Lin Hui-Ping, Perrimon Norbert, Imler Jean-Luc, Hsu Jui-Chou

Abstract excerpt

BACKGROUND: The Drosophila Toll pathway takes part in both establishment of the embryonic dorsoventral axis and induction of the innate immune response in adults. Upon activation by the cytokine Spätzle, Toll interacts with the adaptor proteins DmMyD88 and Tube and the kinase Pelle and triggers degradation of the inhibitor Cactus, thus allowing the nuclear translocation of the transcription factor Dorsal/Dif....

Topics

Adaptor Proteins, Signal Transducing
Animals
Antigens, Differentiation
Body Patterning
Cell Membrane
DNA-Binding Proteins
Dimerization
Drosophila
Drosophila Proteins
Embryo, Nonmammalian
Epistasis, Genetic
Immunity, Innate
Models, Biological

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phenotype

Phosphoproteins

Receptors, Immunologic

Toll-Like Receptors

Source

Open in PubMed

Identifiers

PMID: 16782008
DOI: 10.1016/j.cub.2006.05.050

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