Article
The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults.
Cell - 20 Sept 1996
Lemaitre B, Nicolas E, Michaut L, Reichhart J M, Hoffmann J A
Abstract excerpt
The cytokine-induced activation cascade of NF-kappaB in mammals and the activation of the morphogen dorsal in Drosophila embryos show striking structural and functional similarities (Toll/IL-1, Cactus/I-kappaB, and dorsal/NF-kappaB). Here we demonstrate that these parallels extend to the immune r...
Topics
- Animals
- Antifungal Agents
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Fungi
- Gene Expression
- Genes, Insect
- Genes, MHC Class II
- Insect Hormones
- Insect Proteins
- Membrane Glycoproteins
- Mutation
- Mycoses
- NF-kappa B
- Phosphoproteins
- Proteins
- Receptors, Cell Surface