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Article

The protein kinase Pelle mediates feedback regulation in the Drosophila Toll signaling pathway.

Development (Cambridge, England) - 1 Dec 2001

Towb P, Bergmann A, Wasserman S A

Abstract excerpt

Dorsoventral polarity in the Drosophila embryo is established through a signal transduction cascade triggered in ventral and ventrolateral regions. Activation of a transmembrane receptor, Toll, leads to localized recruitment of the adaptor protein Tube and protein kinase Pelle. Signaling through these components directs degradation of the IkappaB-like inhibitor Cactus and nuclear translocation of the Rel protein...

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Identifiers

PMID: 11731453
DOI: 10.1242/dev.128.23.4729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The protein kinase Pelle mediates feedback regulation in the Drosophila Toll signaling pathway.PMID 11731453Read ↗

Regulated assembly of the Toll signaling complex drives Drosophila dorsoventral patterning.Semantic proximity Read ↗

Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo.Semantic proximity Read ↗

Genetic characterization of tube and pelle, genes required for signaling between Toll and dorsal in the specification of the dorsal-ventral pattern of the Drosophila embryo.Semantic proximity Read ↗

Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity.Semantic proximity Read ↗

Oligomerisation of Tube and Pelle leads to nuclear localisation of dorsal.Semantic proximity Read ↗

Cactus-independent regulation of Dorsal nuclear import by the ventral signal.Semantic proximity Read ↗

Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.Semantic proximity Read ↗

A role for the Drosophila Toll/Cactus pathway in larval hematopoiesis.Semantic proximity Read ↗

The Toll pathway is required in the epidermis for muscle development in the Drosophila embryo.Semantic proximity Read ↗

Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo.Semantic proximity Read ↗

<i>Drosophila</i> MyD88 is an adapter in the Toll signaling pathwaySemantic proximity Read ↗

Regulated nuclear import of Rel proteins in the Drosophila immune response.Semantic proximity Read ↗

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