Article
Regulated assembly of the Toll signaling complex drives Drosophila dorsoventral patterning.
The EMBO journal - 14 Jan 2004
Sun Huaiyu, Towb Par, Chiem Daniel N, Foster Byron A, Wasserman Steven A
Abstract excerpt
In Drosophila, the Toll pathway establishes the embryonic dorsoventral axis and triggers innate immune responses to infection. The transmembrane receptor Toll acts through three death domain-containing proteins, the kinase Pelle and the adapters Tube and MyD88, in signaling to downstream NF-kappaB-like transcription factors. Here, we delineate the critical events in the earliest stages of Toll signaling....
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