Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo.

doi:10.1038/372563a0

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Article

Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo.

Nature - 8 Dec 1994

Grosshans J, Bergmann A, Haffter P, Nüsslein-Volhard C

Abstract excerpt

The concentration of Dorsal protein in the nucleus determines cell fate along the dorsoventral axis of the Drosophila embryo. The dorsal-group genes and the cactus gene are required for production and transmission of a localized signal on the ventral side of the embryo which determines the position of the highest nuclear concentration of Dorsal protein. The ventralizing signal produced in somatic cells is...

Topics

Alleles
Animals
Cloning, Molecular
Drosophila
Drosophila Proteins
Enzyme Activation
Female
Insect Hormones
Membrane Glycoproteins
Protein Serine-Threonine Kinases
Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA

Receptors, Cell Surface

Recombinant Fusion Proteins

Saccharomyces cerevisiae

Signal Transduction

Toll-Like Receptors

Source

Open in PubMed

Identifiers

PMID: 7527496
DOI: 10.1038/372563a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7527496-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo.PMID 7527496Read ↗

The protein kinase Pelle mediates feedback regulation in the Drosophila Toll signaling pathway.Semantic proximity Read ↗

Genetic characterization of tube and pelle, genes required for signaling between Toll and dorsal in the specification of the dorsal-ventral pattern of the Drosophila embryo.Semantic proximity Read ↗

Oligomerisation of Tube and Pelle leads to nuclear localisation of dorsal.Semantic proximity Read ↗

Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity.Semantic proximity Read ↗

Regulated assembly of the Toll signaling complex drives Drosophila dorsoventral patterning.Semantic proximity Read ↗

Cactus-independent regulation of Dorsal nuclear import by the ventral signal.Semantic proximity Read ↗

A role for the Drosophila Toll/Cactus pathway in larval hematopoiesis.Semantic proximity Read ↗

The Toll pathway is required in the epidermis for muscle development in the Drosophila embryo.Semantic proximity Read ↗

A novel function for the IκB inhibitor Cactus in promoting Dorsal nuclear localization and activity in the Drosophila embryo.Semantic proximity Read ↗

cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos.Semantic proximity Read ↗

Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.Semantic proximity Read ↗

Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo.Semantic proximity Read ↗

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