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Article

Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo.

Nature - 8 Dec 1994

Grosshans J, Bergmann A, Haffter P, Nüsslein-Volhard C

Abstract excerpt

The concentration of Dorsal protein in the nucleus determines cell fate along the dorsoventral axis of the Drosophila embryo. The dorsal-group genes and the cactus gene are required for production and transmission of a localized signal on the ventral side of the embryo which determines the position of the highest nuclear concentration of Dorsal protein. The ventralizing signal produced in somatic cells is...

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PMID: 7527496
DOI: 10.1038/372563a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo.PMID 7527496Read ↗

The protein kinase Pelle mediates feedback regulation in the Drosophila Toll signaling pathway.Semantic proximity Read ↗

Genetic characterization of tube and pelle, genes required for signaling between Toll and dorsal in the specification of the dorsal-ventral pattern of the Drosophila embryo.Semantic proximity Read ↗

Oligomerisation of Tube and Pelle leads to nuclear localisation of dorsal.Semantic proximity Read ↗

Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity.Semantic proximity Read ↗

Regulated assembly of the Toll signaling complex drives Drosophila dorsoventral patterning.Semantic proximity Read ↗

Cactus-independent regulation of Dorsal nuclear import by the ventral signal.Semantic proximity Read ↗

A role for the Drosophila Toll/Cactus pathway in larval hematopoiesis.Semantic proximity Read ↗

The Toll pathway is required in the epidermis for muscle development in the Drosophila embryo.Semantic proximity Read ↗

A novel function for the IκB inhibitor Cactus in promoting Dorsal nuclear localization and activity in the Drosophila embryo.Semantic proximity Read ↗

cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos.Semantic proximity Read ↗

Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.Semantic proximity Read ↗

Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo.Semantic proximity Read ↗

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