Article
A novel function for the IκB inhibitor Cactus in promoting Dorsal nuclear localization and activity in the Drosophila embryo.
Development (Cambridge, England) - 15 Aug 2017
Cardoso Maira Arruda, Fontenele Marcio, Lim Bomyi, Bisch Paulo Mascarello, Shvartsman Stanislav Y, Araujo Helena Marcolla
Abstract excerpt
The evolutionarily conserved Toll signaling pathway controls innate immunity across phyla and embryonic patterning in insects. In the Drosophila embryo, Toll is required to establish gene expression domains along the dorsal-ventral axis. Pathway activation induces degradation of the IκB inhibitor Cactus, resulting in a ventral-to-dorsal nuclear gradient of the NFκB effector Dorsal. Here, we investigate how cactus...
Topics
- Alleles
- Animals
- Calpain
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Embryo, Nonmammalian
- Nuclear Proteins
- Phosphoproteins
- Transcription Factors