Article
Molecular basis of basal cell carcinogenesis in the atomic-bomb survivor population: p53 and PTCH gene alterations.
Carcinogenesis - 1 Nov 2006
Mizuno Terumi, Tokuoka Shoji, Kishikawa Masao, Nakashima Eiji, Mabuchi Kiyohiko, Iwamoto Keisuke S
Abstract excerpt
Epidemiological studies suggest that UV exposure from sunlight is the major etiology for skin cancers, both melanocytic and non-melanocytic. However, the radiation-related risk for skin cancer among atomic bomb survivors of Hiroshima and Nagasaki is primarily derived from the excess risk of basal cell carcinoma (BCC), with no demonstrable excess in squamous cell carcinoma or melanoma. The BCCs in this cohort are...
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