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Article

Understanding the Molecular Genetics of Basal Cell Carcinoma.

International journal of molecular sciences - 22 Nov 2017

Pellegrini Cristina, Maturo Maria Giovanna, Di Nardo Lucia, Ciciarelli Valeria, Gutiérrez García-Rodrigo Carlota, Fargnoli Maria Concetta

Abstract excerpt

Basal cell carcinoma (BCC) is the most common human cancer and represents a growing public health care problem. Several tumor suppressor genes and proto-oncogenes have been implicated in BCC pathogenesis, including the key components of the Hedgehog pathway, PTCH1 and SMO, the TP53 tumor suppressor, and members of the RAS proto-oncogene family. Aberrant activation of the Hedgehog pathway represents the molecular...

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Topics

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Share to Carcinoma, Basal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Gene Expression Regulation, Neoplastic

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Share to Loss of Heterozygosity

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Share to Skin Neoplasms

Source

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Identifiers

PMID: 29165358
DOI: 10.3390/ijms18112485
PMCID: PMC5713451

Genes

PTCH1
DPH3
LATS1
MYCN
OXNAD1
PTPN14
SMO
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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