Article
Coding and noncoding somatic mutations in candidate genes in basal cell carcinoma.
Scientific reports - 14 May 2020
Maturo Maria Giovanna, Rachakonda Sivaramakrishna, Heidenreich Barbara, Pellegrini Cristina, Srinivas Nalini, Requena Celia, Serra-Guillen Carlos, Llombart Beatriz, Sanmartin Onofre, Guillen Carlos, Di Nardo Lucia, Peris Ketty, Fargnoli Maria Concetta, Nagore Eduardo, Kumar Rajiv
Abstract excerpt
Basal cell carcinoma (BCC) represents the most commonly diagnosed human cancer among persons of European ancestry with etiology mainly attributed to sun-exposure. In this study we investigated mutations in coding and flanking regions of PTCH1 and TP53 and noncoding alterations in the TERT and DPH3 promoters in 191 BCC tumors. In addition, we measured CpG methylation within the TERT hypermethylated oncological...
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