Article
UV-specific p53 and PTCH mutations in sporadic basal cell carcinoma of sun-exposed skin.
Journal of the American Academy of Dermatology - 1 Feb 2001
Ratner D, Peacocke M, Zhang H, Ping X L, Tsou H C
Abstract excerpt
UVB irradiation is known to produce DNA damage at mutation hotspots in the p53 tumor suppressor gene, leading to the development of skin cancers. Mutations in the PTCH tumor suppressor gene, which is known to be responsible for the development of nevoid basal cell carcinoma syndrome, have also been identified in sporadic basal cell carcinomas (BCCs). We describe the case of an 80-year-old welder in whom 3 novel...
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