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Article

Familial aggregation and linkage analysis of autoantibody traits in pedigrees multiplex for systemic lupus erythematosus.

Genes and immunity - 1 Jul 2006

Ramos P S, Kelly J A, Gray-McGuire C, Bruner G R, Leiran A N, Meyer C M, Namjou B, Espe K J, Ortmann W A, Reichlin M, Langefeld C D, James J A, Gaffney P M, Behrens T W, Harley J B, Moser K L

Abstract excerpt

Autoantibodies are clinically relevant biomarkers for numerous autoimmune disorders. The genetic basis of autoantibody production in systemic lupus erythematosus (SLE) and other autoimmune diseases is poorly understood. In this study, we characterized autoantibody profiles in 1,506 individuals from 229 multiplex SLE pedigrees. There was strong familial aggregation of antinuclear antibodies (ANAs),...

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PMID: 16775618
DOI: 10.1038/sj.gene.6364316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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