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Article

An ancestral haplotype defines susceptibility to doxorubicin nephropathy in the laboratory mouse.

Journal of the American Society of Nephrology : JASN - 1 Jul 2006

Zheng Zongyu, Pavlidis Paul, Chua Streamson, D'Agati Vivette D, Gharavi Ali G

Abstract excerpt

Haplotype analysis was used to refine of the DOXNPH locus, which harbors the susceptibility gene for doxorubicin (DOX; Adriamycin) nephropathy, a Mendelian form of selective podocyte injury. Analysis of haplotype structure in three strains with contrasting susceptibility (148 single-nucleotide polymorphisms at 101-kb spacing) was complementary to analysis of recombinants in 176 F2 mice. For example, haplotype...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16775033
DOI: 10.1681/ASN.2005121373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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