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Article

Protection from doxorubicin-induced cardiac toxicity in mice with a null allele of carbonyl reductase 1.

Cancer research - 15 Oct 2003

Olson Lisa E, Bedja Djahida, Alvey Sara J, Cardounel A J, Gabrielson Kathleen L, Reeves Roger H

Abstract excerpt

Doxorubicin is a highly effective antineoplastic agent, but it can produce the serious side effects of acute cardiac injury and chronic congestive heart failure. Carbonyl reductase (CBR) has been implicated in the development of doxorubicin-induced cardiotoxicity. To test whether a decrease in CBR levels was protective against doxorubicin toxicity, we created a null allele of the Cbr1 gene. Mice with one...

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Identifiers

PMID: 14583452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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