Article
Genotyping the risk of anthracycline-induced cardiotoxicity.
Cardiovascular toxicology - 1 Jan 2007
Deng Shiwei, Wojnowski Leszek
Abstract excerpt
Anthracyclines belong to the most successful antineoplastic drugs, but they are cardiotoxic, which may result in congestive heart failure (CHF). The CHF risk increases with the cumulative anthracycline dose, but it seems also to be modified by individual factors. A role of the individual genetic background is consistent with the altered sensitivity to anthracyclines observed in many transgenic and knockout mouse...
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