Article
Differential cardiotoxicity in response to chronic doxorubicin treatment in male spontaneous hypertension-heart failure (SHHF), spontaneously hypertensive (SHR), and Wistar Kyoto (WKY) rats.
Toxicology and applied pharmacology - 15 Nov 2013
Sharkey Leslie C, Radin M Judith, Heller Lois, Rogers Lynette K, Tobias Anthony, Matise Ilze, Wang Qi, Apple Fred S, McCune Sylvia A
Abstract excerpt
Life threatening complications from chemotherapy occur frequently in cancer survivors, however little is known about genetic risk factors. We treated male normotensive rats (WKY) and strains with hypertension (SHR) and hypertension with cardiomyopathy (SHHF) with 8 weekly doses of doxorubicin (DOX) followed by 12weeks of observation to test the hypothesis that genetic cardiovascular disease would worsen delayed...
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