Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Mendelian locus on chromosome 16 determines susceptibility to doxorubicin nephropathy in the mouse.

Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 2005

Zheng Zongyu, Schmidt-Ott Kai M, Chua Streamson, Foster Kirk A, Frankel Rachelle Z, Pavlidis Paul, Barasch Jonathan, D'Agati Vivette D, Gharavi Ali G

Abstract excerpt

The development of kidney disease is influenced by both genetic and environmental factors. Searching for models of glomerulopathy that display strong gene-environment interaction, we examined the determinants of anthracycline-induced nephropathy, a classic, strain-dependent experimental model applied to rodents in the past four decades. We produced three crosses derived from mice with contrasting susceptibility...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotics, Antineoplastic
Share to Doxorubicin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to In Situ Hybridization

Share to Inbreeding

Share to Kidney Diseases

Share to Mice, Inbred BALB C

Share to Oligonucleotide Array Sequence Analysis

Share to Protein-Arginine N-Methyltransferases

Source

Open in PubMed Open full text

Identifiers

PMID: 15699352
DOI: 10.1073/pnas.0409786102
PMCID: PMC549022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Mendelian locus on chromosome 16 determines susceptibility to doxorubicin nephropathy in the mouse.PMID 15699352Read ↗

An ancestral haplotype defines susceptibility to doxorubicin nephropathy in the laboratory mouse.Semantic proximity Read ↗

Unraveling the Genetic Blueprint of Doxorubicin-Induced Cardiotoxicity Through Systems Genetics ApproachesSemantic proximity Read ↗

Podocyte-specific deletion of Myh9 encoding nonmuscle myosin heavy chain 2A predisposes mice to glomerulopathy.Semantic proximity Read ↗

Population genetics meets precision-cut kidney slices: Nephrotoxicity modelled ex vivo in the founder strains of the BXD mouse consortiumSemantic proximity Read ↗

Genetic loci that affect aristolochic acid-induced nephrotoxicity in the mouse.Semantic proximity Read ↗

Rat Mammary carcinoma susceptibility 3 (Mcs3) pleiotropy, socioenvironmental interaction, and comparative genomics with orthologous human 15q25.1-25.2.Semantic proximity Read ↗

Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice.Semantic proximity Read ↗

Development and Characterization of a Novel FVB-PrkdcR2140C Mouse Model for Adriamycin-Induced Nephropathy.Semantic proximity Read ↗

Genetic predisposition for glomerulonephritis-induced glomerulosclerosis in rats is linked to chromosome 1.Semantic proximity Read ↗

Adriamycin nephropathy: a model of focal segmental glomerulosclerosis.Semantic proximity Read ↗

Identification of novel carcinogen-mediated mammary tumor susceptibility loci in the rat using the chromosome substitution technique.Semantic proximity Read ↗

Fine mapping reveals multiple loci and a possible epistatic interaction within the mammary carcinoma susceptibility quantitative trait locus, Mcs5.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.