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Article

Relationship between the Oligomeric Status of HIV-1 Integrase on DNA and Enzymatic Activity

15 Jun 2006

Abstract excerpt

The 3'-processing of the extremities of viral DNA is the first of two reactions catalyzed by HIV-1 integrase (IN). High order IN multimers (tetramers) are required for complete integration, but it remains unclear which oligomer is responsible for the 3'-processing reaction. Moreover, IN tends to aggregate, and it is unknown whether the polymerization or aggregation of this enzyme on DNA is detrimental or...

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PMID: 16774912
DOI: 10.1074/jbc.m602198200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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