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Article

Oligomerization within Virions and Subcellular Localization of Human Immunodeficiency Virus Type 1 Integrase

1 Jun 1999

Abstract excerpt

Previous biochemical and genetic evidence indicated that the functional form of retroviral integrase protein (IN) is a multimer. A direct demonstration of IN oligomerization during the infectious cycle was, however, missing, due to the absence of a sensitive detection method. We describe here the generation of infectious human immunodeficiency virus type 1 (HIV-1) viral clones carrying IN protein tagged with...

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PMID: 10233971
DOI: 10.1128/jvi.73.6.5079-5088.1999

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