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Article

The replication intermediates in Escherichia coli are not the product of DNA processing or uracil excision.

The Journal of biological chemistry - 11 Aug 2006

Amado Luciana, Kuzminov Andrei

Abstract excerpt

The current model of DNA replication in Escherichia coli postulates continuous synthesis of the leading strand, based on in vitro experiments with purified enzymes. In contrast, in vivo experiments in E. coli and its bacteriophages, in which maturation of replication intermediates was blocked, report discontinuous DNA synthesis of both the lagging and the leading strands. To address this discrepancy, we analyzed...

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PMID: 16772291
DOI: 10.1074/jbc.M602320200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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