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Article

Unequal fidelity of leading strand and lagging strand DNA replication on the Escherichia coli chromosome.

Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 1998

Fijalkowska I J, Jonczyk P, Tkaczyk M M, Bialoskorska M, Schaaper R M

Abstract excerpt

We have investigated the question whether during chromosomal DNA replication in Escherichia coli the two DNA strands may be replicated with differential accuracy. This possibility of differential replication fidelity arises from the distinct modes of replication in the two strands, one strand (the leading strand) being synthesized continuously, the other (the lagging strand) discontinuously in the form of short...

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Identifiers

PMID: 9707593
DOI: 10.1073/pnas.95.17.10020
PMCID: PMC21454

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