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Article

Roles of topoisomerase IV and DNA gyrase in DNA unlinking during replication in Escherichia coli.

Genes & development - 15 Nov 1995

Zechiedrich E L, Cozzarelli N R

Abstract excerpt

For a cell to complete DNA replication, every link between the Watson-Crick strands must be removed by topoisomerases. Previously, we reported that the inhibition of topoisomerase IV (topo IV) leads to the accumulation of catenated plasmid replicons to a steady-state level of approximately 10%. Using pulse labeling with [3H]thymidine in Escherichia coli, we have found that in the absence of topo IV activity,...

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Identifiers

PMID: 7590259
DOI: 10.1101/gad.9.22.2859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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