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Article

RuvAB acts at arrested replication forks.

Cell - 30 Oct 1998

Seigneur M, Bidnenko V, Ehrlich S D, Michel B

Abstract excerpt

Replication arrest leads to the occurrence of DNA double-stranded breaks (DSB). We studied the mechanism of DSB formation by direct measure of the amount of in vivo linear DNA in Escherichia coli cells that lack the RecBCD recombination complex and by genetic means. The RuvABC proteins, which catalyze migration and cleavage of Holliday junctions, are responsible for the occurrence of DSBs at arrested replication...

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Identifiers

PMID: 9814711
DOI: 10.1016/s0092-8674(00)81772-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

RuvAB acts at arrested replication forks.PMID 9814711Read ↗

RuvABC is required to resolve holliday junctions that accumulate following replication on damaged templates in Escherichia coli.Semantic proximity Read ↗

The RuvAB branch migration translocase and RecU Holliday junction resolvase are required for double-stranded DNA break repair in Bacillus subtilis.Semantic proximity Read ↗

ruvA Mutants that resolve Holliday junctions but do not reverse replication forks.Semantic proximity Read ↗

The DNA repair helicase UvrD is essential for replication fork reversal in replication mutants.Semantic proximity Read ↗

Abortive recombination in Escherichia coli ruv mutants blocks chromosome partitioning.Semantic proximity Read ↗

Loss of lambda prophage recombinogenicity in UV-irradiated Escherichia coli: the role of host genes ruvA, ruvB, ruvC, and recG.Semantic proximity Read ↗

Formation of a stable RuvA protein double tetramer is required for efficient branch migration in vitro and for replication fork reversal in vivo.Semantic proximity Read ↗

Escherichia coli RuvBL268S: a mutant RuvB protein that exhibits wild-type activities in vitro but confers a UV-sensitive ruv phenotype in vivo.Semantic proximity Read ↗

RuvAB is essential for replication forks reversal in certain replication mutants.Semantic proximity Read ↗

Escherichia coli RuvC protein is an endonuclease that resolves the Holliday structure.Semantic proximity Read ↗

Molecular mechanisms of Holliday junction processing in Escherichia coli.Semantic proximity Read ↗

The RuvABC resolvasome.Semantic proximity Read ↗

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