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Article

Low-molecular-weight DNA replication intermediates in Escherichia coli: mechanism of formation and strand specificity.

Journal of molecular biology - 15 Nov 2013

Amado Luciana, Kuzminov Andrei

Abstract excerpt

Chromosomal DNA replication intermediates, revealed in ligase-deficient conditions in vivo, are of low molecular weight (LMW) independently of the organism, suggesting discontinuous replication of both the leading and the lagging DNA strands. Yet, in vitro experiments with purified enzymes replicating sigma-structured substrates show continuous synthesis of the leading DNA strand in complete absence of ligase,...

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Identifiers

PMID: 23876705
DOI: 10.1016/j.jmb.2013.07.021
PMCID: PMC3812275

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Source receipt: pubmed, retrieved 7 Sept 2026.

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