Article
Contribution of OCTN variants within the IBD5 locus to pediatric onset Crohn's disease.
The American journal of gastroenterology - 1 Jun 2006
Babusukumar Umesh, Wang Tao, McGuire Erin, Broeckel Ulrich, Kugathasan Subra
Abstract excerpt
BACKGROUND & AIMS: The IBD5 locus on chromosome 5q31 is a confirmed Crohn's disease (CD) susceptibility locus in adults. Recently, two polymorphisms in the organic cation transporter (OCTN) gene cluster within the IBD5 locus have been found to be associated with CD. Although the original report of significant linkage to IBD5 was in families with at least one case of early age at onset CD, there are no published...
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