Article

Identification of Marker Immunoglobulin Rearrangements for Use by HAT-PCR in Myeloma

2026-06-29

Abstract excerpt

Libraries for next generation sequencing were prepared using primers directed to the framework 2, framework 3 and D and J regions of the rearranged immunoglobulin gene from 50 diagnosis myeloma bone marrow samples. After sequencing and bioinformatic analysis a marker sequence suitable for minimal residual disease analysis by HAT-PCR was obtained for 90% of the 50 samples studied. In 88% of samples a complete VDJ s...

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Literature Corpus work: 80659165-ffcb-516f-ab3d-124a8b3ada94
DOI: 10.20944/preprints202606.2076.v1

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