Article
Differential and limited expression of mutant alleles in multiple myeloma.
Blood - 13 Nov 2014
Rashid Naim U, Sperling Adam S, Bolli Niccolo, Wedge David C, Van Loo Peter, Tai Yu-Tzu, Shammas Masood A, Fulciniti Mariateresa, Samur Mehmet K, Richardson Paul G, Magrangeas Florence, Minvielle Stephane, Futreal P Andrew, Anderson Kenneth C, Avet-Loiseau Herve, Campbell Peter J, Parmigiani Giovanni, Munshi Nikhil C
Abstract excerpt
Recent work has delineated mutational profiles in multiple myeloma and reported a median of 52 mutations per patient, as well as a set of commonly mutated genes across multiple patients. In this study, we have used deep sequencing of RNA from a subset of these patients to evaluate the proportion of expressed mutations. We find that the majority of previously identified mutations occur within genes with very low...
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