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Article

Acidic fibroblast growth factor decreases alpha-smooth muscle actin expression and induces apoptosis in human normal lung fibroblasts.

American journal of physiology. Lung cellular and molecular physiology - 1 Nov 2006

Ramos Carlos, Montaño Martha, Becerril Carina, Cisneros-Lira José, Barrera Lourdes, Ruíz Victor, Pardo Annie, Selman Moisés

Abstract excerpt

Fibroblast/myofibroblast expansion is critical in the pathogenesis of pulmonary fibrosis. To date, most research has focused on profibrotic mediators, whereas studies on antifibrotic factors are scanty. In this study, we explored the effects of acidic fibroblast growth factor (FGF-1) and FGF-1 plus heparin (FGF-1+H) on fibroblast growth rate, apoptosis, and myofibroblast differentiation. Heparin was used because...

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Identifiers

PMID: 16766579
DOI: 10.1152/ajplung.00019.2006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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