Article

Hypoxia modulates human pulmonary arterial adventitial fibroblast phenotype through HIF-1α activation

2025-01-29

Abstract excerpt

Hypoxic pulmonary hypertension (HPH) develops in association with diseases characterized by low oxygen levels leading to pulmonary artery (PA) narrowing and death. Hypoxia has been linked to increased PA collagen and changes in PA adventitial fibroblast (PAAF) metabolism. However, the mechanisms by which hypoxia regulates PAAF function are unknown. Hypoxia-inducible factor-1α (HIF-1α) is a subunit of a transcripti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 52ce689e-24e9-5d9b-a86a-30cd21f5554b
DOI: 10.1101/2025.01.27.635152

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hypoxia modulates human pulmonary arterial adventitial fibroblast phenotype through HIF-1α activationDOI 10.1101/2025.01.27.635152Read

Hypoxia Inducible Factor-1α in Pulmonary Fibrosis: A Promising Therapeutic TargetSemantic proximity Read

The Effect of Hypoxia-inducible Factor Inhibition on the Phenotype of Fibroblasts in Human and Bovine Pulmonary Hypertension.Semantic proximity Read

Hypoxic mast cells accelerate the proliferation, collagen accumulation and phenotypic alteration of human lung fibroblasts.Semantic proximity Read

Functional Repercussions of Hypoxia-Inducible Factor-2α in Idiopathic Pulmonary FibrosisSemantic proximity Read

Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms.Semantic proximity Read

Hypoxia signaling in human diseases and therapeutic targetsSemantic proximity Read

Branched chain α-ketoacids aerobically activate HIF1α signaling in vascular cellsSemantic proximity Read

Hypoxia in Cancer and Fibrosis: Part of the Problem and Part of the SolutionSemantic proximity Read

Unraveling the role of HIF and epigenetic regulation in pulmonary arterial hypertension: implications for clinical research and its therapeutic approachSemantic proximity Read

Comparative Expression Profiling in Pulmonary Fibrosis Suggests a Role of Hypoxia-inducible Factor-1α in Disease PathogenesisSemantic proximity Read

Expression of hypoxia-inducible factor 1: mechanisms and consequencesSemantic proximity Read

Microenvironmental Regulation of Macrophage Transcriptomic and Metabolomic Profiles in Pulmonary HypertensionSemantic proximity Read