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Article

Focal adhesion kinase signaling determines the fate of lung epithelial cells in response to TGF-β.

American journal of physiology. Lung cellular and molecular physiology - 1 Jun 2017

Ding Qiang, Subramanian Indhu, Luckhardt Tracy R, Che Pulin, Waghray Meghna, Zhao Xue-Ke, Bone Nathaniel, Kurundkar Ashish R, Hecker Louise, Hu Meng, Zhou Yong, Horowitz Jeffrey C, Vittal Ragini, Thannickal Victor J

Abstract excerpt

Alveolar epithelial cell (AEC) injury and apoptosis are prominent pathological features of idiopathic pulmonary fibrosis (IPF). There is evidence of AEC plasticity in lung injury repair response and in IPF. In this report, we explore the role of focal adhesion kinase (FAK) signaling in determining the fate of lung epithelial cells in response to transforming growth factor-β1 (TGF-β1). Rat type II alveolar...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Transforming Growth Factor beta

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Identifiers

PMID: 28360109
DOI: 10.1152/ajplung.00121.2016
PMCID: PMC5495945

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SMAD3

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