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Article

Diverse signaling pathways regulate fibroblast differentiation and transformation through Rho kinase activation.

Journal of cellular physiology - 1 May 2007

Harvey Kevin A, Paranavitana Corine Nivanka, Zaloga Gary P, Siddiqui Rafat A

Abstract excerpt

This study examined the role of agonist-induced Rho kinase (ROCK) involvement in the morphological outcome of pulmonary-derived fibroblasts. Normal human lung fibroblasts (NHLF) spontaneously differentiate into network-like structures in a two-dimensional growth factor reduced Matrigel matrix-based assay. Sphingosine 1-phosphate (SPP), a bioactive phospholipid that regulates angiogenesis, inhibited fibroblast...

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Identifiers

PMID: 17167780
DOI: 10.1002/jcp.20939

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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