Article
Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.
Molecular biology of the cell - 1 Jun 2004
Shi-Wen Xu, Chen Yunliang, Denton Christopher P, Eastwood Mark, Renzoni Elisabetta A, Bou-Gharios George, Pearson Jeremy D, Dashwood Michael, du Bois Roland M, Black Carol M, Leask Andrew, Abraham David J
Abstract excerpt
The endothelins are a family of endothelium-derived peptides that possess a variety of functions, including vasoconstriction. Endothelin-1 (ET-1) is up-regulated during tissue repair and promotes myofibroblast contraction and migration, hence contributing to matrix remodeling during tissue repair. Here, we show that addition of ET-1 to normal lung fibroblasts induces expression of proteins that contribute to a...
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