Article
Activation of the pro-survival phosphatidylinositol 3-kinase/AKT pathway by transforming growth factor-beta1 in mesenchymal cells is mediated by p38 MAPK-dependent induction of an autocrine growth factor.
The Journal of biological chemistry - 9 Jan 2004
Horowitz Jeffrey C, Lee Daniel Y, Waghray Meghna, Keshamouni Venkateshwar G, Thomas Peedikayil E, Zhang Hengmin, Cui Zongbin, Thannickal Victor J
Abstract excerpt
Transforming growth factor-beta1 (TGF-beta1) is a multifunctional cytokine involved in differentiation, growth, and survival of mesenchymal cells while inhibiting growth/survival of most other cell types. The mechanism(s) of pro-survival signaling by TGF-beta1 in mesenchymal cells is unclear. In this report, we demonstrate that TGF-beta1 protects against serum deprivation-induced apoptosis of mesenchymal cells...
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