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Article

Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development.

The EMBO journal - 12 Jul 2006

Kim Myungjin, Lee Jun Hee, Koh Hyongjong, Lee Soo Young, Jang Cholsoon, Chung Cecilia J, Sung Jung Hwan, Blenis John, Chung Jongkyeong

Abstract excerpt

Although p90 ribosomal S6 kinase (RSK) is known as an important downstream effector of the ribosomal protein S6 kinase/extracellular signal-regulated kinase (Ras/ERK) pathway, its endogenous role, and precise molecular function remain unclear. Using gain-of-function and null mutants of RSK, its physiological role was successfully characterized in Drosophila. Surprisingly, RSK-null mutants were viable, but...

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Identifiers

PMID: 16763554
DOI: 10.1038/sj.emboj.7601180
PMCID: PMC1500987

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